Lipids as central mediators of cellular signalling

Receptor protein tyrosine phosphatases as mediators of cellular adhesion.

Receptor protein tyrosine phosphatases (RPTPs) are structurally characterized by the diversity of their extracellular domains (ECDs). These domains display Ig-like, fibronectin type III (FNIII), MAM (meprin, A5, PTPmu), and carbonic anhydrase (CAH) motifs that resemble those present in many cell adhesion molecules (CAMs). However, in contrast to most CAMs, RPTPs also contain an intracellular do...

Ubiquitin as a central cellular regulator

That most protein molecules do not last as long as the cell in which they reside was suggested more than 60 years ago, by studies that utilized stable isotopes to label proteins in vivo (Schoenheimer, 1942). Despite this evidence, the prevailing view, until the 1980s, was that intracellular protein degradation was a simple and even mundane process, serving largely to dispose of "aged" or otherw...

The cellular lipids of Romboutsia.

We have examined the lipids of three isolates, Romboutsia lituseburensis, Romboutsia ilealis, and Romboutsia sp. strain FRIFI, of the newly described genus Romboutsia by two-dimensional thin-layer chromatography (2D-TLC) and by liquid chromatography/mass spectrometry (LC/MS). We have found three phospholipids, phosphatidylglycerol (PG), cardiolipin and phosphatidic acid in all three species. A ...

Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

Skin surface lipid (SSL) film is a mixture of sebum and keratinocyte membrane lipids, protecting skin from environment. Its composition is unique for the high percentage of long chain fatty acids, and of the polyterpenoid squalene, absent in other human tissues, and in non-human Primates sebum. Here, the still incomplete body of information on SSL as mediators of external chemical, physical, an...

Playing "telephone": bioactive lipids as mediators of intercompartmental communication in the alveolus.